痴呆症中的心理药物多药:对患有神经精神病症状的人进行回顾性分析,转介给澳大利亚痴呆症支持服务
Mustafa Atee1,2,3,4, Andrew Stafford5, Daniel Whiting6
1The Dementia Centre, HammondCare, Level 2, 302 Selby Street Nth, Osborne Park, WA, 6017, Australia. matee@dementia.com.au.
Drugs & aging
|January 21, 2025
概括
心理药物多药在澳大利亚痴呆症患者中很常见,超过一半接受多种心理药物治疗. 没有特定的患者因素与这种广泛的处方实践有关.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 临床药学和药理学 临床药学和药理学
- 神经科学和神经病学 神经科学和神经病学
背景情况:
- 精神药物经常被处方用于痴呆症神经精神症状 (NPS),尽管益处有限且副作用显著.
- 精神药物多药,定义为同时使用两种或两种以上的精神药物,不推用于痴呆症患者,因为风险增加.
研究的目的:
- 确定澳大利亚痴呆症患者中精神药物多药的流行率,寻求NPS的外部支持.
- 在这个人群中调查心理药物多药与人口因素或NPS特征之间的联系.
主要方法:
- 一项回顾性横截面研究分析了2016年至2020年期间来自痴呆症支持澳大利亚 (DSA) 转诊的基线数据.
- 人口统计数据,NPS类型,严重程度 (使用神经精神病学目录 - NPI) 和护理人员痛苦在与没有心理药物多药物治疗的个人之间进行了比较.
- 统计分析包括千平方测试,韦尔奇的t测试和逻辑回归模型来评估关系.
主要成果:
- 在421个分析的转诊中,90%以上涉及至少一种精神药物.
- 在 50.8% (n=214) 的队列中发现了心理药物多种药物,其中抗精神病药物,阿片类药物和抗焦虑药物是常见的.
- 精神药物多药与患者人口统计 (年龄,性别,痴呆亚型) 或NPI严重程度之间没有发现显著的关联.
结论:
- 心理药物多药在澳大利亚痴呆症患者中非常普遍,并转移到专门的支持服务.
- 该研究没有确定与这种队列中精神药物多药性存在相关的特定患者相关因素.
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