在患有格雷夫斯病的患者中,25-氧维生素D的有益水平可降低甲状腺氨酸受体抗体 (TRAB):现实研究
Xide Chen1,2,3,4,5,6, Yongze Zhang1,2,3,4,5,6, Luxi Lin1,2,3,4,5,6
1Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
BMC endocrine disorders
|January 21, 2025
概括
新确诊的格雷夫斯病 (GD) 和足够的25-氧维生素D水平 (20-29 ng/mL) 的患者在抗甲状腺治疗期间表现出改善的甲状腺素受体抗体 (TRAB) 减少. 这表明维生素D状态会影响GD治疗结果.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 格雷夫斯病 (GD) 是一种影响甲状腺的自身免疫性疾病.
- 甲状腺素受体抗体 (TRAB) 水平是GD活性和治疗反应的关键指标.
- 维生素D在包括GD在内的自身免疫性疾病中的作用是正在进行的研究领域.
研究的目的:
- 调查治疗前25-氧维生素D水平与新诊断的格雷夫斯病患者的TRAB缓解和负转化率之间的关联.
- 为了确定特定的基线25-基维生素D水平是否与改善的治疗结果相关.
主要方法:
- 分析了171名新诊断的格雷夫斯病患者的队列.
- 根据基线25-基维生素D水平,患者被分为三组:<20 ng/mL,20-29 ng/mL和≥30 ng/mL.
- 甲状腺素受体抗体 (TRAB) 缓解和负转化率在6,12和24个月后进行评估.
主要成果:
- 基线25-基维生素D水平在20-29ng/mL之间的患者在所有随访点都表现出显著更高的TRAB缓解和负转化率.
- 20-29 ng/mL组在初始诊断时显示出较高的TSH和较低的TRAB标位.
- 基线25-基维生素D水平与随访期间FT3,FT4或TSH水平的正常化没有相关性.
结论:
- 足够的基线25-氧维生素D水平 (20-29 ng/mL) 与在接受抗甲状腺治疗的新诊断的格雷夫斯病患者中改善的TRAB减少有关.
- 维生素D状况可能是影响GD治疗疗效的可修改因素.
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