不基于胰岛素的胰岛素耐药替代品制造商与Helicobacter pylori感染之间的关联:基于人口的研究
Jiayu Qiu1, Yueming Yu1, Dingwei Liu1
1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
胰岛素耐药性 (IR) 的非胰岛素标志物,如甘油三糖 (TyG) 指数,与美国成年人的Helicobacter pylori (H. pylori) 感染有积极联系. 这些标记可能有助于识别H. pylori感染风险.
科学领域:
- 代谢健康和传染病
背景情况:
- 关于胰岛素耐药性 (IR) 和Helicobacter pylori (H. pylori) 感染之间的联系的证据有限.
- 不基于胰岛素的IR替代标记,包括甘油三糖 (TyG) 指数,甘油三与高密度脂蛋白胆固醇 (TG/HDL-C) 比率以及IR代谢得分 (METS-IR) 越来越多地被使用.
研究的目的:
- 调查非胰岛素基础的红外替代标记与美国人口中的H. pylori感染之间的关联.
- 使用各种统计模型和子组分析来探索潜在的相关性.
主要方法:
- 1999-2000年美国国家健康和营养检查调查 (NHANES) 的939名参与者的横截面研究.
- 使用后勤回归,受限立方线 (RCS) 曲线和子组分析来评估红外线标志物和H. pylori感染之间的关联.
主要成果:
- 患有H. pylori感染的参与者表现出三种IR替代标记物的水平明显升高.
- 在所有三种IR标志物和H. pylori感染之间观察到积极的关联,即使在调整混因子后也是如此.
- 亚组分析表明女性和非西班牙裔白人更强烈的关联. RCS曲线显示了TyG指数和METS-IR的线性相关性,以及TG/HDL-C比率与H. pylori感染的非线性相关性.
结论:
- 非胰岛素基础的IR替代标记 (TyG指数,TG/HDL-C比率,METS-IR) 与H. pylori感染有积极的关联.
- 这些标记物可能作为识别美国人口中H. pylori感染风险的指标.
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