单热量高脂肪饮食在没有肥胖的情况下降低了动机
Kenny Arbuckle1, Reema Sharma1, Frannie E Drake1,2
1Behavioral and Systems Neuroscience, Psychology Department, Rutgers University, Piscataway, New Jersey, USA.
Obesity (Silver Spring, Md.)
|January 22, 2025
概括
高脂肪饮食 (HFD) 即使没有导致肥胖,也可以改变行为. 这项研究发现,同热量高度缩剂在小鼠中降低了对糖的动机,这表明仅仅饮食暴露可以推动与肥胖相关的行为变化.
科学领域:
- 行为神经科学 行为神经科学
- 代谢研究研究 代谢研究
- 饮食影响研究 饮食影响研究
背景情况:
- 众所周知,肥胖饮食会导致身体活动和动机的持久变化.
- 目前尚不清楚这些行为转变是由于体重增加或直接的饮食暴露.
研究的目的:
- 研究高脂肪饮食 (HFD) 对小鼠身体活动,食物动机和昼夜模式的影响,特别是在没有显著体重增加的情况下.
- 区分肥胖和HFD暴露对行为的影响.
主要方法:
- 小鼠每天大约80%的卡路里来自HFD (同热量食) 以及自由选择的食.
- 测量包括每周的体重,体力活动,昼夜模式,操作行为和代谢标记.
- 在同热量养后,小鼠接受了随意的HFD,以评估体重增加和活动变化.
主要成果:
- 同热量的HFD并没有显著增加体重或改变身体活动水平.
- 暴露于同热量的HFD降低了对糖颗粒的动机.
- 在此背景下,随后的随意HFD暴露没有显示变化的体重增加.
结论:
- 一个同热量的HFD导致了对糖的动机减少,反映了动物肥胖模型中的发现.
- 这些结果表明,接触肥胖性饮食可以诱导与肥胖相关的行为变化,而不依赖于显著的体重增加.
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