在多中心研究中,使用3T FLAIR*进行中枢静脉信号成像的可靠性*
Melissa Lynne Martin1,2, Quy Cao1,2, Elaina Luskin3
1Penn Statistics in Imaging and Visualization Endeavor, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
概括
3T FLAIR* MRI上的中央静脉标志 (CVS) 在多发性硬化症 (MS) 诊断的不同成像站点和供应商中是可靠的. 加多对比显著提高了CVS的显眼性,支持其临床使用.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 中枢静脉标志 (CVS) 是多发性硬化症 (MS) 的关键成像生物标志物.
- 在3特斯拉 (3T) 的FLAIR*MRI为检测CVS提供了高显著性.
- 确保CVS在不同环境中检测的可靠性对于临床应用至关重要.
研究的目的:
- 在多个成像站点和MRI供应商中评估3T FLAIR*对CVS显著性的可靠性.
- 为了确定加多 (Gd) 的对比度是否会在3T FLAIR*上增强CVS的可见性.
主要方法:
- 一项多中心研究涉及87名成年人,在9个地点怀疑患有MS.
- 高分辨率T2*加权和T2加权的FLAIR脑图像在3T时从两个供应商那里获得,Gd前后对比.
- 损伤与静脉对比与噪音比率 (CNR损伤与静脉) 被计算出来,以量化CVS显著性.
主要成果:
- 在成像站点或MRI供应商之间,无论是Gd前后的FLAIR*,都没有发现平均CNR损伤到静脉的显著差异.
- 在Gd后的FLAIR*与Gd前的FLAIR*相比,CVS显著性的统计学上显著增加 (p < 0.001).
结论:
- 使用3T FLAIR*的CVS显著性在各种临床成像环境和MRI制造商中是一致且可靠.
- 加多对比剂在3T FLAIR*上显著提高了CVS的可见性.
- 这些发现支持将FLAIR*成像技术纳入MS诊断的常规临床实践.
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