相关实验视频

Updated: Jun 1, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

通过双向门德尔随机化阐明炎症蛋白和心房风险之间的因果动力学

Yuan Lv^1,2, Bin Huang^1,2, Liyin Xu³

¹Department of Cardiology, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China.

Current molecular medicine

|January 22, 2025

概括

炎症在心房动 (AF) 中起着因果作用. 七种炎症蛋白与AF风险有关,其中三种增加风险,四种具有保护作用,表明潜在的生物标志物和治疗点.

科学领域:

心血管医学心血管医学
遗传学遗传学是一个
免疫学免疫学免疫学

背景情况:

心房动 (AF) 是一种常见的心律失常,与高发病率和死亡率有关.
在AF的发展中怀疑炎症,但与特定蛋白质的因果关系尚不清楚.
这项研究调查了炎症蛋白和AF风险之间的因果关系.

研究的目的:

澄清循环炎症蛋白与心房动 (AF) 风险之间的因果关系.
使用孟德尔随机化评估炎症蛋白和AF之间的双向关系.
确定AF的潜在生物标志物和治疗点.

主要方法:

使用了双向的两样本门德尔随机化 (MR) 方法.
分析了91种循环炎症蛋白质的基因变异作为仪器变量.
评估了这些蛋白对AF风险的影响,反之亦然.

主要成果:

七种炎症蛋白与AF风险有显著关联.
纤维细胞生长因子5 (FGF-5),瘤坏死因子 (TNF) 和介素二受体子单元β (IL-2RB) 增加了AF风险.
CD40连接体受体 (CD40),与Fms相关的氨酸激酶3连接体 (FIt3L),白血病抑制因子受体 (LIF-R) 和硫转移酶1A1 (ST1A1) 显示出对AF的保护作用.
反向MR分析表明,AF对炎症蛋白水平没有显著影响,这表明有单向因果关系.

结论:

这项研究提供了强有力的证据,证明特定的炎症蛋白和AF风险之间存在因果关系.
已识别的蛋白质可以作为AF风险分层的生物标志物.
这些发现为AF干预提供了潜在的治疗目标,并为其病理生理学提供了新的见解.

关键词:

心房动是一种心房动.心血管遗传学. 心血管遗传学.遗传流行病学遗传流行病学炎症性蛋白质是一种炎症性蛋白质.门德尔的随机化是门德尔的随机化

更多相关视频

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Published on: September 24, 2021

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

相关概念视频

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...