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Updated: Jun 1, 2025

Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry
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Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Published on: September 3, 2010

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远程深紫外线激光切除与电喷射电离-大气压化学电离 (rDUVLAESCI) 相结合:用于分子质谱的新型双电离源

Barbora Papoušková1, Petr Fryčák1, Filip Gregar1

  • 1Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, 17. Listopadu 12, 77146 Olomouc, Czech Republic.

Analytical chemistry
|January 22, 2025
PubMed
概括

一个新的激光除系统使指纹的各种分子能够同时进行质谱分析. 这项技术精确地可视化和识别物质,改善复杂样本的个体识别.

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Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

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Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
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Matrix-Assisted Laser Desorption Ionization (MALDI)01:08

Matrix-Assisted Laser Desorption Ionization (MALDI)

Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI spectrometry is widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.
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Chemical Ionization (CI) Mass Spectrometry

The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ionization can lead to the rapid dissociation of some molecular ions before they reach the detector. A milder ionization method is required to increase the lifetime of such ionized analyte molecules. Chemical ionization (CI) is a gas-phase protonation reaction useful for mass-analyzing analyte molecules that are easily protonated to yield the...
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Mass Spectrometry: Overview

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Mass Spectrometers

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