大脑表面积和功能变化与末期病患者的认知相关
Chi Wang1, Lijun Song2, Xu Liu3
1Department of Radiology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Quantitative imaging in medicine and surgery
|January 22, 2025
概括
末期病 (ESRD) 患者由于皮质结构和功能变化而表现出显著的认知衰退. 血液透析加剧了这些变化,特别是在中间叶,恶化ESRD患者的认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
背景情况:
- 认知能力下降在末期病 (ESRD) 中普遍存在,特别是在接受血液透析的患者中.
- 关联认知障碍和ESRD的潜在机制尚不清楚.
- 皮质结构和功能变化与ESRD患者的认知衰退有关.
研究的目的:
- 研究ESRD患者皮质结构和功能变化与认知衰退之间的相关性.
- 在非透析ESRD,血液透析ESRD和健康对照中比较认知功能和大脑变化.
主要方法:
- 126名参与者 (40名ESRD-ND,40名ESRD-HD,46名HC) 接受了神经心理测试和MRI.
- 分析了皮层厚度,体积和静止状态功能连接 (ReHo).
- 在大脑指标和认知得分 (MoCA) 之间进行了相关性分析.
主要成果:
- 与HC相比,ESRD患者表现出较低的中部皮层厚度和体积.
- 血液透析进一步减少了中部皮质和前带膜/中部前额皮质的体积.
- 在ESRD患者中,中叶和后带带状回形变化与认知得分 (MoCA) 相相关.
结论:
- ESRD与影响认知的显著皮质结构和功能变化有关.
- 血液透析似乎会恶化或诱导新的大脑区域变化.
- 后侧带带状回环和中间叶损伤是ESRD认知衰退的关键因素,透析加剧了中间叶损伤.
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