内镜手术会影响肠道微生物群及其新陈代谢,乳腺癌患者
Jingtai Li1, Fangfang Gao1, Runwei Li2
1The First Clinical School of Hainan Medical University, Department of Breast Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Frontiers in microbiology
|January 22, 2025
概括
乳腺癌的内镜手术会改变肠道微生物群和代谢物. 术后管理应侧重于肠道微生物群的调整,以改善患者的康复和健康结果.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 代谢学 代谢学 代谢学
背景情况:
- 内镜手术对乳腺癌患者有好处,但其对肠道微生物群的影响尚不清楚.
- 肠道微生物群对整体健康和雌激素代谢起着至关重要的作用.
- 需要进一步的研究来澄清内镜手术对乳腺癌患者肠道微生物群的影响.
研究的目的:
- 研究内镜手术对乳腺癌患者肠道微生物群组成和代谢概况的影响.
- 为了确定与内镜乳腺癌手术相关的特定微生物和代谢变化.
- 探索这些变化对患者康复和健康的影响.
主要方法:
- 从20名接受内镜手术的乳腺癌患者收集了便样本.
- 用16S rRNA测序分析了肠道微生物组成.
- 代谢物被用液体染色学-双重质谱法 (LC-MS/MS) 鉴定,随后进行生物信息学和统计分析.
主要成果:
- 内镜手术导致肠道微生物群多样性和组成的微妙变化,包括减少了Lachnospiraceae和Monoglobaceae.
- 观察到代谢物概况的显著变化,影响了诸如初级胆酸生物合成和酸盐代谢等途径.
- 一种特定的脂,PE ((PGD1/18:1 ((9Z))),被确定为一个关键的代谢物,在手术后增加,与其他与不同的细菌种类相关的化合物一起.
结论:
- 经过内镜手术的乳腺癌患者表现出改变的肠道微生物群和代谢概况.
- 术后管理策略应考虑肠道微生物群调节,以改善患者的康复.
- 针对肠道微生物群的调整可能会改善乳腺癌患者在内镜术后的健康结果.
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