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Updated: Jun 1, 2025

Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
塞维拉默诱导的胃肠粘膜损伤:临床医师的批判性审查
Lefika Bathobakae1, Phenyo Phuu2, Saif Yasin2
1Internal Medicine, St. Joseph's University Medical Center, Paterson, USA.
塞维拉默晶体沉积可以在血液透析患者中引起胃肠道损伤. discontinuation of sevelamer通常可以消除症状,但严重的病例可能需要切除.
科学领域:
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学 是一个学科.
背景情况:
- 塞维拉默是一种酸盐结合剂,用于血液透析的末期脏病 (ESRD) 患者的高酸血症.
- 塞维拉默晶体沉积在肠道中可能导致严重的粘膜损伤 (SIGMI).
- 由于SIGMI的罕见性和医生意识较低,SIGMI的发病率和流行率在很大程度上是未知的.
研究的目的:
- 为提供sevelamer诱导的胃肠粘膜损伤 (SIGMI) 的概述.
- 专注于SIGMI的病因学,表现,发病,诊断和管理.
- 系统地审查关于SIGMI的现有案例报告.
主要方法:
- 对案例报告和案例系列进行系统审查.
- 搜索了电子数据库 (PubMed,Embase,Google Scholar) 从创立到2023年8月的时间.
- 在过了1239个初始结果后,包含了28篇相关文章.
主要成果:
- 梅琳娜和腹部疼痛是最常见的症状.
- 在75%的患者中,停止sevelamer治疗导致临床改善或症状消失.
- 22%的患者由于穿孔或亡等严重并发症需要进行大肠切除.
结论:
- SIGMI 是在血液透析患者中使用塞维拉默的罕见但显著并发症.
- 及时诊断和管理对于预防严重后果至关重要.
- 需要进一步的研究来了解SIGMI的全部范围.
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