环境超细粒子与学前儿童神经发育迟缓之间的关联在中国上海,中国
Mengxun Rong1, Yang Shen1, Yihui Ge1
1Department of Environmental Health, School of Public Health, Fudan University, 130 Dong-An Road, Shanghai 200032, China.
Environment & health (Washington, D.C.)
|January 22, 2025
概括
儿童早期接触超细颗粒物 (UFP) 与神经发育迟缓的风险更高有关. 这项研究发现,在中国学龄前儿童中,与UFP暴露相关的毛细运动技能延迟的可能性增加.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 超细颗粒物 (UFP,颗粒≤0.1μm) 被怀疑是神经毒性.
- 关于UFP对神经发育的影响的人类数据仍然有限,特别是在幼儿时期.
研究的目的:
- 调查住宿UFP暴露与中国学龄前儿童神经发育迟缓之间的关联.
- 评估粗细运动技能的风险.
主要方法:
- 在中国上海,共有11,230名3至5.5岁的儿童参加了这项调查.
- 使用高分辨率的土地使用回归模型 (50米) 估计了住宅UFP暴露.
- 通过使用年龄和阶段问卷 (ASQ-3) 评估神经发育;统计分析使用了通用线性混合模型.
主要成果:
- 中位数的UFP暴露为24,478颗颗粒/cm3.
- 每次UFP暴露的四分位数间范围 (IQR) 增加都与8%更高的怀疑粗运动延迟的几率相关 (OR,1.08;95% CI,1.02-1.15).
- 每次UFP暴露的IQR增加都与12%更高的疑似精细运动延迟 (OR,1.12;95% CI,1.02-1.22) 的几率有关,并观察到剂量反应关系.
结论:
- 儿童早期接触UFP与大脑神经发育迟缓的风险增加有关.
- 调查结果强调了城市环境中UFP的潜在神经发育风险.
- 需要进一步的研究来证实这些关联并探索潜在的机制.
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