非HDL-C/HDL-C比率与骨矿物质密度之间的关系:一项NHANES研究
Shuo Qi1, Biao Peng2, Zhanwang Xu3
1The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Frontiers in nutrition
|January 22, 2025
概括
非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率 (NHHR) 与骨矿物质密度 (BMD) 有负相关性,特别是在具有较低BMI的年轻男性中. 控制NHHR可以改善骨健康并预防骨质疏松症.
科学领域:
- 脂质代谢 脂质代谢是什么
- 骨健康 骨健康 骨健康
- 骨质疏松症研究 骨质疏松症研究
背景情况:
- 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率 (NHHR) 是一个新兴的脂质参数.
- 关于NHHR与腰椎以外的骨矿物质密度 (BMD) 以及其风险因素的相关性,研究有限.
研究的目的:
- 在不同地点调查NHHR和BMD之间的关联.
- 确定影响NHHR-BMD关系的风险因素.
- 提高对脂质水平对骨健康的影响的理解.
主要方法:
- 利用了来自8,671名参与者的国家健康和营养检查调查 (NHANES) 数据 (2011-2018).
- 采用单变量和通用线性模型 (GLM),分层分析和平滑曲线拟合.
- 将NHHR水平分类为三级 (低,中,高).
主要成果:
- 在多个地点,NHHR显示了与BMD的分层负相关性.
- 这种关联在BMI低至中等 (<25 kg/m2),男性和年轻年龄组 (18-30岁) 个体中显著.
- 在男性 (腰椎,全身) 中,NHHR对BMD的影响更为明显,并且随着年龄的增长而减弱.
结论:
- NHHR对BMD的影响是由BMI,性别和年龄调节的.
- 控制NHHR可能是骨健康管理的可行策略,特别是在风险人群中.
- 这些发现为脂质-骨代谢相互作用提供了新的视角,并支持个性化骨质疏松症策略.
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