认知障碍的年龄相关表型作为SARS-CoV-2感染的后果
Gabriela Gonzalez Aleman1, George D Vavougios2,3, Carmela Tartaglia4,5
1Department of Psychology, School of Psychology and Psychopedagogy, Universidad Catolica Argentina, Buenos Aires, Argentina.
Frontiers in aging neuroscience
|January 22, 2025
概括
在COVID-19 (PASC) 后的认知变化显示出特定年龄的模式. 老年人经历更严重的记忆,语言和执行功能问题,与急性疾病严重程度和嗅觉丧失有关.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 后急性后续COVID-19 (PASC) 可以表现为认知变化.
- 认知障碍在不同人群和不同年龄段可能有所不同.
研究的目的:
- 在不同的人群中调查PASC认知变化的统一性.
- 在PASC患者中识别特定年龄的认知障碍概况和风险因素.
主要方法:
- 个人层面的综合分析和认知评估的元分析.
- 包括2105名患者和1432名来自八个国际前队列的对照.
- 对认知表现,年龄,感染诊断和嗅觉功能障碍的统计分析.
主要成果:
- 根据原产国,没有发现认知障碍的显著差异.
- 年轻和中年人表现出轻度注意力障碍.
- 老年人表现出更严重的记忆,语言和执行功能的损伤,中度至重度损伤的风险增加了一倍.
- 严重的损伤与感染诊断和厌氧症 (嗅觉丧失) 的严重程度有关.
结论:
- 在PASC中存在明显的与年龄相关的认知障碍表型.
- 急性疾病的严重程度和嗅觉功能障碍是老年人从COVID-19中恢复过来的痴呆症类认知障碍的关键预测因素.
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