脑小血管疾病与认知障碍的潜在生物标志物:系统性审查和元分析
Libin Liao1, Weiquan Huang1, Rongchao Ma1
1Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Frontiers in aging neuroscience
|January 22, 2025
概括
循环homocysteine (Hcy) 和高灵敏性C反应蛋白 (hs-CRP) 是诊断大脑小血管疾病 (CSVD) 认知障碍的潜在生物标志物. 升高的水平表明风险更高,有助于早期发现和治疗这种常见的与年龄有关的疾病的策略.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 老年病的医生 老年病的医生
背景情况:
- 大脑小血管疾病 (CSVD) 是与年龄相关的认知障碍和痴呆的主要原因.
- 与CSVD相关的认知障碍 (CSVD-CI) 构成了日益严重的全球健康挑战,影响老年人群,并造成重大社会经济负担.
- 循环生物标志物正在成为诊断,监测和预测CSVD-CI.结果的关键工具.
研究的目的:
- 在CSVD患者中,系统地审查和元分析循环因素与认知障碍之间的关联.
- 评估已识别的循环因子作为CSVD-CI的诊断生物标志物的潜力.
主要方法:
- 在PubMed,Web of Science,Embase和Cochrane图书馆进行了系统的文献搜索,寻找2023年11月之前发表的研究.
- 从2,911个初始记录中选择了29篇相关文章.
- 对报告四种潜在生物标志物的研究进行了元分析:同类氨酸 (Hcy),高灵敏性C反应蛋白 (hs-CRP),脂蛋白相关脂酶A2 (Lp-PLA2) 和神经丝蛋白轻链 (NfL).
主要成果:
- 分析显示,与CSVD-CI患者相比,与CSVD患者但没有认知障碍患者相比,CSVD-CI患者的同型半氨酸 (Hcy) 和高灵敏度C反应蛋白 (hs-CRP) 水平显著升高.
- 在CSVD-CI和CSVD没有认知障碍组之间没有观察到Lp-PLA2和NfL水平的统计学上显著差异.
- Hcy和hs-CRP显示出作为可靠的循环标记物,用于识别CSVD中的认知障碍的潜力.
结论:
- 同型氨酸 (Hcy) 和高灵敏性C反应蛋白 (hs-CRP) 被确定为与大脑小血管疾病相关的认知障碍的有希望的循环生物标志物.
- 这些生物标志物可能有助于早期临床检测和诊断CSVD-CI.
- 进一步的研究可以探索将Hcy和hs-CRP整合到临床实践中,用于管理CSVD患者.
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