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艾滋病毒/艾滋病和物质使用的神经影响改变了大脑功能和结构
James Haorah1, Samikkannu Malaroviyam1, Hemavathi Iyappan1
1Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, United States.
Frontiers in medicine
|January 22, 2025
概括
药物使用通过改变大脑细胞功能,使艾滋病毒相关的神经认知障碍 (HAND) 恶化. 了解这些分子变化是开发针对持久性HANDs的新治疗方法的关键.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染导致获得免疫缺陷综合征 (AIDS).
- 联合抗逆转录病毒疗法 (cART) 可以控制艾滋病,但与艾滋病毒相关的神经认知障碍 (HAND) 仍然存在.
- 药物使用通过促进HIV复制和神经病变发生,加剧了HAND.
研究的目的:
- 审查艾滋病毒和物质使用对HANDs的并发症影响.
- 探索分子,细胞类型和大脑区域机制,这些机制是HAND持久性的基础.
- 突出微质和表观基因组修饰在HAND神经病变发生过程中的作用.
主要方法:
- 审查有关艾滋病毒,物质使用和HANDs的现有文献.
- 对翻译后修改和微质特异性生物标志物的分析.
- 探索表观基因组修饰,包括N端乙化.
主要成果:
- 艾滋病毒和物质使用协同破坏微质功能,影响神经通信.
- 表观基因组修饰,特别是N端乙化,在微质中起着至关重要的作用.
- 损坏的微质蛋白质有助于HANDs的神经退行.
结论:
- 了解艾滋病毒,物质使用和微细胞之间的分子相互作用对于解决HAND持续性至关重要.
- 针对表观基因组修饰和微质功能可能为HANDS提供治疗策略.
- 在预防物质使用中介的神经病变发生方面,cART的有效性需要进一步研究.
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