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Updated: May 12, 2026

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将基因型信息纳入精确的预测模型,用于在上皮卵巢癌中对白金敏感性的预测

Nai-Yi Du1, Yan Li2, Hui Zheng3

  • 1Department of Gynecology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Frontiers in oncology
|January 22, 2025
PubMed
概括

这项研究开发了一种使用遗传数据的预测模型,以识别可能对化疗有反应的上皮卵巢癌患者. 该模型准确地区分了药物敏感和耐药病例,从而实现了个性化治疗策略.

关键词:
临床因素 临床因素药物敏感性 药物敏感性上皮卵巢癌 卵巢癌 卵巢癌预测模型的预测模型.一个核酸的多态性.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...