与COVID-19相关睡眠问题相关的功能连接性改变:一个纵向休息状态fMRI研究
Hao-Bo Chen1, Ling Li2, Yun-Kai Sun2
1Department of Radiology, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, People's Republic of China.
Nature and science of sleep
|January 22, 2025
概括
患有睡眠问题的COVID-19幸存者表现出大脑连接的改变. 这些功能连接变化在两个月内演变,可能解释了感染后持续的睡眠问题.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 传染性疾病 传染性疾病
背景情况:
- COVID-19经常与持续的疲劳和睡眠障碍有关.
- 后COVID-19睡眠问题的潜在神经生物学机制在很大程度上仍然未被描述.
研究的目的:
- 为了调查与COVID-19幸存者的睡眠问题相关的大脑功能连接 (FC) 的变化.
- 在两个月的时间内探索这些FC变化的时间动态.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于55名患有睡眠问题 (COVID_SP) 和33名没有 (COVID_NSP) 的COVID-19幸存者.
- 参与者完成了匹兹堡睡眠质量指数 (PSQI),并在基线和2个月后进行了rs-fMRI.
- 使用皮尔森相关性与高斯随机场校正分析了FC和临床数据之间的相关性,R-M ANOVA探索了时间相互作用.
主要成果:
- 在基线时,COVID_SP在包括前中心,下叶和海马体在内的区域表现出升高的FC.
- 左海马和右上额头之间更高的FC与PSQI得分相关.
- 随访时,FC变化涉及情绪调节,执行功能和记忆,而其他区域显示了与注意力和处理相关的FC增加;这些变化与临床得分相关,并显示了显著的时间相互作用效应.
结论:
- 这项研究揭示了COVID-19后与睡眠问题相关的大脑功能连接的显著变化.
- 这些神经成像发现为COVID-19后睡眠障碍的病理生理学提供了洞察力.
- 观察到的FC变化的时间演变表明,这是一个动态过程,可能会导致睡眠问题的持续.
关键词:
在 COVID-19 疫情中,美国FC FC FCSP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SPrs-fMRI 是一个更多相关视频
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