我们是否应该将基于微生物群的干预措施视为精神分裂症的新型治疗策略? 一个系统的审查和元分析
Lucas Hassib1,2, Alexandre Kanashiro3, João Francisco Cordeiro Pedrazzi4
1Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Brain, behavior, & immunity - health
|January 22, 2025
概括
肠道微生物群的操纵显示了改善精神分裂症症状的希望. 这次元分析发现,针对肠道微生物组的干预措施导致精神分裂症患者的症状明显改善.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 微生物学 微生物学
背景情况:
- 精神分裂症是一种复杂的精神疾病,具有多因素的病因.
- 由于症状异质性,目前的治疗方法面临着挑战.
- 新兴研究将肠道微生物组的改变与精神分裂症联系起来.
研究的目的:
- 调查肠道微生物群操纵在改善精神分裂症患者精神病结局方面的有效性.
- 分析关于针对精神分裂症的微生物向干预措施的现有研究.
主要方法:
- 9项研究的系统综述和元分析 (n=417).
- 包括随机对照试验和低偏差风险的开放标签研究.
- 分析了使用效果大小计算 (Hedges' g) 的症状改善.
主要成果:
- 综合效果大小表明症状明显改善 (黑奇斯的g = 0.48,p = 0.004).
- 效果大小小到中等,研究异质性中等.
- 乳杆菌和Bifidobacterium属显示出潜在的益处.
结论:
- 肠道微生物群的操纵可能为精神分裂症提供一种新的治疗途径.
- 需要进一步的高质量试验来确认疗效,并通过肠-大脑轴探索机制.
- 基于微生物组的疗法可以作为主要或辅助治疗.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
314
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
314
Bacterial Flora of the Large Intestine
376
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
376
Biological Causes of Schizophrenia
37
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
37
What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K


