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Updated: Jun 1, 2025

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嗅觉功能障碍作为神经退行性疾病中的潜在生物标志物:叙述性综述
Nicolas De Cleene1, Katarína Schwarzová1, Samuel Labrecque1
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Frontiers in neuroscience
|January 22, 2025
概括
嗅觉功能障碍,嗅觉的下降,往往是诸如阿尔茨海默氏症和帕金森氏症等神经退行性疾病的先兆. 这表明嗅觉测试可以早期检测这些情况.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物标志物研究 生物标志物研究
背景情况:
- 神经退行性疾病涉及逐渐失去神经元,导致认知和运动能力下降.
- 嗅觉功能障碍 (OD),嗅觉障碍,越来越多地与阿尔茨海默病 (AD),帕金森病 (PD),亨廷顿病 (HD) 和骨髓缩侧面硬化症 (ALS) 相关.
- OD可以在其他临床症状之前表现出来,这表明它可能是早期或前期生物标志物.
研究的目的:
- 审查当前关于阿尔茨海默病,PD,ALS和HD嗅觉功能障碍的知识.
- 评估OD作为这些神经退行性疾病早期生物标志物的潜力.
- 探索与OD相关的神经病理和神经递质改变.
主要方法:
- 关于神经退行性疾病中的嗅觉功能障碍研究的综合文献综述.
- 关于常见的嗅觉功能的测量技术的总结.
- 分析神经病理相关性和神经递质系统变化.
主要成果:
- 嗅觉功能障碍是多种神经退行性疾病中常见的早期特征.
- 特定的OD模式可能与不同的疾病病理相关.
- 神经病理变化和神经递质变化是这些条件下OD的基础.
结论:
- 嗅觉功能障碍显示出作为神经退行性疾病早期和前性生物标志物的显著前景.
- 进一步研究OD机制和标准化测试对于临床应用至关重要.
- 了解OD可以改善对AD,PD,ALS和HD的早期诊断和干预策略.
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