益生菌作为创伤后应激障碍的辅助疗法:试点随机对照试验
Robin M Voigt1,2,3, Phillip A Engen1, Michelle Villanueva1
1Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, United States.
Frontiers in neuroscience
|January 22, 2025
概括
这项研究调查了益生菌纤维补充剂是否可以改善接受认知行为治疗 (CBT) 的退伍军人创伤后应激障碍 (PTSD) 症状. 结果表明,患有PTSD的个体的一个子集可能会从这种微生物群修饰干预中受益.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究的研究.
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 是一种精神健康状况,通常伴有胃肠道问题.
- 像认知行为疗法 (CBT) 这样的当前治疗方法是有效的,但并不普遍成功.
- 在PTSD患者的肠道微生物组中发生的干扰 (失生症) 可能会导致神经炎症,这表明微生物组调节作为治疗点.
研究的目的:
- 评估与CBT结合的益生菌纤维干预对退伍军人的PTSD临床结果的影响.
- 探索PTSD症状严重程度,肠道微生物群组成和短链脂肪酸 (SCFA) 水平之间的关系.
- 评估使用益生菌补充剂作为PTSDCBT辅助的可行性和可接受性.
主要方法:
- 这是一项为期12周的双盲,安慰剂对照试验,涉及70名患有PTSD的退伍军人.
- 参与者接受了CBT与益生菌纤维或CBT与安慰剂.
- 在治疗开始和结束时评估PTSD症状严重程度,肠道微生物群组成和SCFA水平 (乙酸盐,酸盐,丁酸盐).
主要成果:
- 创伤后应激障碍的严重程度可能与产生SCFA propionate的细菌数量较低有关.
- 一组患有PTSD的退伍军人通过微生物群修饰益生菌干预措施显示出临床改善.
- 发现益生菌干预是可行的,并可接受作为CBT的辅助.
结论:
- 用益生菌补充剂向肠道微生物群显示有望提高PTSD治疗结果.
- 微生物群调制可以作为一种有价值的辅助或替代治疗策略,用于特定的个人与创伤后应激障碍.
- 需要进一步的研究来阐明PTSD中肠-大脑轴背后的机制.
相关概念视频
Post-traumatic Stress Disorder
27
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
27
Introduction to Stress and Lifestyle
73
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
73
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
314
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
314
Drugs for Treatment of Diarrhea-Predominant IBS
145
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
145
Irritable Bowel Syndrome I: Introduction
243
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
243


