移植瘤学和抗癌免疫抑制剂
Dejun Kong1, Jinliang Duan1, Shaofeng Chen1
1Nankai University School of Medicine, Tianjin, China.
Frontiers in immunology
|January 22, 2025
概括
开发具有抗瘤特性的新型免疫抑制剂对于移植患者至关重要,特别是那些患有移植后恶性瘤高风险的人. 本综述探讨了提供免疫抑制和抗癌益处的药物.
科学领域:
- 移植瘤学 移植瘤学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 器官移植可以挽救生命,但需要长期的免疫抑制.
- 免疫抑制会增加移植后的癌症风险,特别是在肝脏移植接受者之前患有肝癌时.
- 移植瘤学旨在改善高风险患者的治疗结果.
研究的目的:
- 为了确定具有双重抗瘤和免疫抑制功能的免疫抑制剂.
- 为了支持高瘤复发风险的移植患者的管理.
主要方法:
- 对现有文献进行系统审查.
- 探索具有抗癌作用的潜在免疫抑制药物.
- 对mTOR抑制剂和像capecitabine这样的抗代谢物进行分析.
主要成果:
- mTOR 抑制剂显示出抗瘤作用.
- 在肝移植患者的肝细胞癌中,capecitabine可能具有免疫抑制作用.
- 新出现的证据表明,双重作用药物是可行的.
结论:
- 临床上需要具有联合抗瘤和免疫抑制性质的免疫抑制剂.
- 对mTOR抑制剂和capecitabine等药物的进一步研究是有必要的.
- 这些药物可以显著改善患有恶性瘤风险的移植受体的结果.
相关概念视频
Tumor Immunotherapy
467
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
467
Tissue Transplantation
334
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
334
Bone Marrow Sampling and Transplants
277
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
277
Cell-mediated Immune Responses
66.8K
Overview
66.8K
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Cancer Vaccines
332
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
332


