托科醇对慢性病患者心血管风险标志物的影响:一项随机对照试验
Liana Trugilho1, Lívia Alvarenga1,2, Ludmila Cardozo3,4
1Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.
Journal of nutrition and metabolism
|January 22, 2025
概括
富含托科特里昂醇的富分量 (TRF) 补充剂在血液透析患者中降低了LDL胆固醇和总胆固醇,并在非透析慢性病 (CKD) 患者中降低了C反应蛋白. 在CKD中,TRF可能会减轻心血管风险.
科学领域:
- 营养生物化学和心血管健康
- 慢性病 (CKD) 的临床试验方法.
背景情况:
- 患有慢性病 (CKD) 的患者面临由于失脂症,炎症和氧化应激导致的心血管风险增加.
- 托科特里昂醇,维生素E异构体,显示出对抗这些风险的营养策略的潜力.
研究的目的:
- 评价富含托科特里昂醇分数 (TRF) 补充剂在缓解慢性病患者氧化应激和炎症标志物的有效性.
- 评估TRF对非透析 (ND) 和血液透析 (HD) 中心血管风险因素的影响.
主要方法:
- 一个为期3个月的双盲,安慰剂控制,随机的临床试验,涉及33名CKD患者 (17 HD, 16 ND).
- 参与者每天补充300毫克TRF或安慰剂.
- 评估的标记物包括介质素-6 (IL-6),瘤缩因子-α (TNF-α),C反应蛋白 (CRP),脂质过氧化和NRF2/NF-κBmRNA表达.
主要成果:
- 在血液透析 (HD) 患者中,TRF补充剂显著降低了LDL胆固醇 (p=0.04) 和血总胆固醇 (p=0.01).
- 在非透析 (ND) 的CKD患者中,TRF显著降低了血清C反应蛋白 (CRP) 水平 (p=0.05).
- 在这两组中都没有观察到NRF2和NF-κBmRNA表达的显著变化.
结论:
- 富含托科特里昂醇的部分 (TRF) 补充剂在缓解慢性病患者的失脂症和炎症方面显示出潜在的潜力.
- 在血液透析和非透析CKD人群中,TRF的有效性可能会有所不同,这表明了量身定制的营养策略.
- 特朗普基金会要求进一步调查作为一种营养干预措施,以减少慢性病中心血管风险.
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