同甲基化网络与青春期的认知和结构性大脑发育有关
Dawn Jensen1,2, Jiayu Chen1,3, Jessica A Turner4
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University), Atlanta, GA, United States.
表观遗传变化,特别是DNA甲基化,与青少年大脑发育相关. 神经元基因中的这些DNA甲基化模式与这个关键发育时期的认知和大脑成熟有关.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
背景情况:
- 青少年神经发育涉及灰色物质 (GM) 体积,髓化 (微分异型 - FA) 和认知功能的变化.
- 人们假设表观遗传修饰,如DNA甲基化 (DNAm),在这些发育过程中起作用.
研究的目的:
- 研究DNA甲基化模式与青少年大脑发育之间的关系.
- 确定与青春期认知和神经影像测量相关的特定联合甲基化网络.
主要方法:
- 对正常发育的青少年 (9-14岁) 的长度研究.
- 收集了认知评估,唾液DNAm和神经成像数据 (GM,FA).
- 利用权重基因相关网络分析 (WCGNA) 识别联合甲基化网络,并评估它们与大脑和认知措施的关联.
主要成果:
- 在整个青春期观察到相关表观遗传变化的增加.
- 确定了为神经元通路 (例如,通道,神经素,神经蛋白) 丰富的联合甲基化网络.
- 这些网络随着时间的推移而得到保护,并且与GM,FA和认知表现的成熟有关.
结论:
- 神经元基因中的相关DNAm变化与青少年大脑成熟有关.
- 这些发现表明,青少年时期的认知和大脑发育背后存在潜在的表观遗传机制.
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