"农业最佳实践"成功地有助于减少牛奶农场内的抗生素耐药性基因丰度.
Barbara Salerno1, Matteo Cornaggia2, Raffaella Sabatino3
1Laboratory of Microbial Ecology and Genomics, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Frontiers in veterinary science
|January 22, 2025
概括
实施最佳农业实践显著减少了牛奶农场的抗生素耐药基因 (ARG). 谨慎的抗生素使用和卫生是控制耐药性传播的关键,特别是在哺乳期的奶牛中.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 环境科学 环境科学
背景情况:
- 农场是抗生素耐药细菌和基因 (ARG) 传播的关键枢纽.
- 减少ARG传播对于公众和动物健康至关重要.
- 需要有效的农场管理策略来打击抗生素耐药性.
研究的目的:
- 评估"农业最佳实践"指南对减少ARG丰富性的影响.
- 评估干预措施在奶牛场环境中的有效性.
主要方法:
- 在10个奶牛农场实施了一项促进谨慎使用抗生素和卫生的指南.
- 在实施指南之前和之后,从奶牛和小牛收集了便样本.
- 抗生素耐药基因 (ARG) 用PCR和数字滴滴PCR量化.
主要成果:
- 哺乳期母牛的ARG含量最高.
- 尽管持续使用抗生素,但总ARG丰度,特别是blaTEM和tetA,在指南发布后显著下降.
- 该研究表明,在最佳实践实施后,特定的ARG减少了.
结论:
- 农业的最佳实践,包括谨慎使用抗生素和改善卫生,有效地减少ARG的丰富性.
- 哺乳母牛是控制抗生素耐药性传播的干预措施的关键目标.
- 研究结果支持采用基于证据的农业实践来缓解抗生素耐药性.
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