严重肺炎的老年患者的凝血参数:与疾病严重程度和预后的相关性
Qiuyue Zhang1, Yingchao Liu1, Chuntang Tong2
1Department of Clinical Laboratory, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, People's Republic of China.
Infection and drug resistance
|January 22, 2025
概括
在患有严重肺炎的老年患者中,凝血异常很常见. 升高的前列血时间和D-二次体水平预示着这个患者群体的预后和死亡率不佳.
科学领域:
- 老年医学 老年医学
- 肺部病理学 肺部病理学
- 血液学 血液学 血液学
背景情况:
- 严重的肺炎经常影响老年人,往往导致严重的发病率和死亡率.
- 凝血系统的失调越来越被认为是严重肺炎结果的关键因素.
研究的目的:
- 在被诊断患有严重肺炎的老年患者中调查凝血参数水平.
- 分析这些凝血参数,疾病严重程度和患者预后之间的相关性.
主要方法:
- 对207名严重肺炎的老年患者 (≥60岁) 进行了回顾性分析.
- 收集的数据包括人口统计信息,临床特征和凝血标志物 (前血时间,激活的部分血栓塑时间,血时间,纤维素因子).
- 为了进行比较分析,患者根据28天死亡率被分为幸存者和非幸存者组.
主要成果:
- 28天的死亡率为52.2%.
- 与幸存者相比,未幸存者表现出显著更高的前列血时间和D-二元水平,以及较低的纤维素原水平 (p < 0.05).
- 多变量分析确定高血时间 (OR=1.218) 和D-二次数 (OR=1.109) 作为28天死亡率的独立风险因素. 一个组合模型显示出强大的预测值 (AUC=0.801).
结论:
- 凝血功能障碍是严重肺炎的老年患者普遍出现的并发症.
- 输血红素时间和D-二次数水平是评估疾病严重程度和预测这一人口中的预后的有价值指标.
相关概念视频
01:30Pneumonia III: Complications and Assessment
153
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
153
01:28Pneumonia IV: Management
296
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
296
01:29Pneumonia II: Pathophysiology
211
The pathophysiology of pneumonia involves the following steps:
211
01:30Pneumonia I: Introduction
205
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
205
01:30Pneumonia V: Nursing management and Prevention
1.8K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
1.8K