由于暴露于寒冷而引起的性交感神经活动的逐渐增加
Misa Yoshimoto1, Kana Yagi1, Shizuka Ikegame1
1Autonomic Physiology Laboratory, Faculty of Life Science and Human Technology, Nara Women's University, Japan.
Hypertension (Dallas, Tex. : 1979)
|January 22, 2025
概括
暴露于寒冷会激活交感神经活动 (SNA),导致高血压. 这项研究表明,感冒累积增加脏SNA,这表明自我激活的途径启动高血压.
科学领域:
- 心血管生理学心血管生理学
- 环境医学 环境医学
- 神经科学是一个神经科学.
背景情况:
- 寒冷的环境可以通过激活交感神经活动 (SNA) 和损害巴罗受体反射来触发高血压.
- 在感冒引起的高血压期间直接测量SNA和巴罗反射控制并未得到充分理解.
研究的目的:
- 在感冒引起的高血压期间直接测量交感神经活动 (SNA).
- 为了调查SNA在寒冷暴露的反应中巴罗反射控制的变化.
主要方法:
- 鼠被暴露在寒冷 (10°C) 中4天,同时测量脏和腰部交感神经活动 (SNA).
- 通过使用血管活性药物操纵动脉压来生成SNA和心率的巴罗反射曲线.
主要成果:
- 脏SNA (RSNA) 在暴露于寒冷期间逐渐增加,并在之后保持高位,表明累积效应.
- 寒冷暴露提高了交感驱动的最大容量,RSNA巴罗反射曲线向右和向上转移.
- 腰部SNA,心率和动脉压在感冒期间增加,但在暴露结束后恢复到基线.
结论:
- 暴露于寒冷会对脏SNA产生依赖时间的累积效应,增加其最大驱动能力.
- 由于暴露于寒冷,RSNA的自我激活途径被启动,有助于导致寒冷的高血压.
- 虽然腰部SNA和心率的影响是可逆的,但RSNA持续的变化表明,感冒引起的高血压的持续机制.
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