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细菌细胞外囊泡在动脉样硬化开始,进展和治疗中的作用

Yuling Lin^1,2, Jingyu Wang¹, Fan Bu³

¹Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

|January 22, 2025

概括

细菌细胞外囊泡 (BEVs) 是动脉样硬化中的关键参与者,影响肠心轴通信. 本综述探讨了它们在疾病进展和治疗潜力中的作用.

科学领域:

微生物学微生物学
心血管科学心血管科学
胃肠病学胃肠病学

背景情况:

动脉样硬化驱动心血管和脑血管疾病,由于目前的药物限制,需要新的治疗方法.
人们越来越认识到肠道微生物群在动脉样硬化中的作用,重点从代谢物转移到细菌细胞外囊泡 (BEVs).
细菌细胞外囊泡 (BEVs),细菌分泌的脂质双层,正在成为动脉样硬化中宿主微生物群相互作用的重要媒介.

研究的目的:

阐明在动脉样硬化中沿肠心轴经由BEVs介导的通讯途径.
总结BEVs在促进动脉样硬化 (病原体衍生) 和减轻其进展 (共生体/益生菌衍生) 中的双重作用.
探索工程 BEV 对于动脉样硬化预防和治疗的潜力和挑战.

主要方法:

文献综述总结了关于BEVs和动脉样硬化的当前知识.
对BEV参与宿主微生物群相互作用的分析.
探索使用工程 BEV 的治疗策略.

主要成果:

病原体衍生的BEV可以促进动脉样硬化发展.
来自肠道共生生物和益生菌的BEV显示出缓解动脉样硬化进展的潜力.
工程 BEV 为新的治疗干预提供了有希望的途径.

结论:

BEVs代表了与动脉样硬化相关的肠心轴通信中的关键接口.
了解BEV功能对于开发有针对性的疗法和诊断工具至关重要.
为了推进动脉样硬化管理,需要对BEV进行进一步的研究,包括工程变体.

关键词:

细菌的细胞外囊泡.动脉样硬化动脉样硬化在外膜囊泡中,外膜囊泡

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