基于乳酸氧化酶的多功能人工过氧体作为一种自我级联增强活性氧放大器,用于瘤治疗
Huihui Wang1,2, Xueping Huang1, Ran Gao1
1Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China.
ACS applied materials & interfaces
|January 22, 2025
概括
这项研究引入了一种使用LOX-Ce6-Mn (LCM) 纳米颗粒的新型多式模式癌症治疗策略. 液晶菌有效地消耗乳酸盐,并产生活性氧物种 (ROS),用于协同化学动力学和光动力学疗法,抑制瘤生长.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 癌症的复杂性需要多模式的协同治疗策略.
- 开发用于组合疗法的新药对于有效的癌症治疗至关重要.
研究的目的:
- 为了合成和评估一种新的氧气自我养的氧体乳酸氧化酶 (LOX) 基纳米粒子 (LOX-Ce6-Mn,LCM).
- 调查LCM在级化学动力学疗法 (CDT) 和光动力学疗法 (PDT) 癌症治疗中的疗效.
主要方法:
- 生物矿物化方法用于合成LCM纳米粒子.
- 研究了LCM在瘤细胞中耗尽乳酸盐并产生反应性氧物种 (ROS) 的能力.
- 在体外和体内评估的CDT/PDT联合效应.
主要成果:
- LCM纳米颗粒将内源的H2O2转化为O2,促进乳酸消耗和缓解瘤缺氧.
- 在光照射后,LCM增强了单点氧 (1O2) 的产生,并通过芬顿式反应产生基基 (•OH).
- 显著促进ROS积累,抑制瘤生长,并诱导自.
结论:
- 这种LCM有效地重编程瘤细胞代谢和瘤微环境.
- 通过结合CDT和PDT,LCM提供了一种有前途的多式联络策略,用于协同治疗癌症.
相关概念视频
Peroxisomes
9.9K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
9.9K
Peroxisomes and Mitochondria
86.5K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
86.5K


