复杂性的适应性进化轨迹:单细胞性和可选择差异化的多细胞性之间的过渡.
Hanna Isaksson1,2, Peter Lind2,3,4, Eric Libby1,2,4
1Department of Mathematics and Mathematical Statistics, Umeå University, Umeå 90187, Sweden.
概括
进化压力可以驱使单细胞生物转向多细胞或细胞分化. 然而,持续的压力可能会导致复杂性增加或恢复单细胞性,这取决于突变顺序和适应性权衡.
科学领域:
- 进化生物学是进化的生物学.
- 理论生物学的理论生物学.
- 生命的起源 生命的起源
背景情况:
- 多细胞性从简单的细胞群到复杂的生物体.
- 简单的多细胞性在选择性压力下很容易发展.
- 增加多细胞复杂性的演变并未得到充分理解.
研究的目的:
- 研究单细胞生物在周期性非生物性压力下的适应性轨迹.
- 确定有利于多细胞化,细胞分化或两者的条件.
- 探索突变如何影响复杂性的进化.
主要方法:
- 在周期性压力下单细胞群体的数学建模.
- 定义一个适应性相关特征的参数空间.
- 模拟有益突变对适应性轨迹的影响.
主要成果:
- 多细胞性和分化为应对压力提供了生存的好处,但在缺乏压力时会产生成本.
- 健身环境决定了最佳的策略 (单细胞,多细胞或分化).
- 突变顺序 (历史偶然性) 可以影响复杂性过渡的永久性.
结论:
- 对多细胞性的持续选择性压力可能会导致复杂性增加或回归单细胞性.
- 适应性轨迹可能涉及获得和失去复杂性的循环.
- 复杂性的进化对突变顺序和适应性权衡非常敏感.
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