健康老龄化和艾滋病毒感染者和未感染者的肠道微生物群
Brandilyn A Peters1, Xiaonan Xue1, David B Hanna1
1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
The Journal of infectious diseases
|January 22, 2025
概括
年龄影响肠道微生物群,影响多样性和特定细菌,如Akkermansia和Prevotella. 这些与年龄相关的微生物组变化与健康结果有关,例如艾滋病毒感染或不感染的两种性别的脆弱性和死亡风险.
科学领域:
- 微生物组研究的研究.
- 衰老和健康 衰老和健康
- 人类免疫缺陷病毒 (HIV) 研究研究
背景情况:
- 与衰老相关的并发症在艾滋病毒感染者中比未感染者更为普遍.
- 肠道微生物组在健康老龄化中的作用尚未得到充分研究,特别是在艾滋病毒的背景下.
- 了解这些联系对于制定有针对性的健康干预措施至关重要.
研究的目的:
- 调查时间年龄与肠道微生物组的组成和多样性之间的关联.
- 探索这些与年龄相关的微生物组变化如何与健康指标如脆弱性和死亡风险有关.
- 根据性别和艾滋病毒状况,检查这些关联中的潜在差异.
主要方法:
- 来自大量男性和女性的便样本的16S rRNA基因测序 (MACS/WIHS联合队列研究).
- 分析肠道微生物群的多样性,独特性和与年龄相关的属级丰富性.
- 已识别的与衰老相关的微生物属与脆弱性和死亡风险指标的相关性 (炸脆性表型,VACS指数).
主要成果:
- 高龄与增加的微生物群多样性和Akkermansia和Streptococcus的丰富性相关,并减少了Prevotella和Faecalibacterium.
- 来自18个属的"与衰老相关的微生物组评分"随着年龄的增长而增加,独立于其他因素.
- 年龄与微生物组的关联因性别和艾滋病毒状况而异,在没有艾滋病毒的男性中更强,但在有艾滋病毒和没有艾滋病毒的女性中相似.
结论:
- 时间学年龄始终改变男性和女性的肠道微生物组,无论艾滋病毒状况如何.
- 特定的与年龄相关的肠道微生物与健康的下降有关,包括虚弱和死亡风险增加.
- 这些发现突出了肠道微生物群作为促进不同人群健康衰老的干预措施的潜在目标.
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