瓶刷糊作为无溶剂,可注射和形状持久材料的平台,具有组织模拟粘性弹性
Jessica Garcia1, Foad Vashahi1, Akmal Z Umarov2
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill 27599, United States.
ACS applied materials & interfaces
|January 22, 2025
概括
可注射弹性体是在没有溶剂或反应的情况下创建的,使用建筑障碍的玻璃化瓶刷移植共聚合物. 这种无溶剂的方法为重建外科和组织工程中的应用提供了可调节的特性.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
背景情况:
- 目前注射材料通常依赖于溶剂和化学反应,导致诸如不受控制的胀和组织副作用等问题.
- 需要无溶剂注射材料,具有可调节的机械性能,用于生物医学应用.
研究的目的:
- 开发一种新的无溶剂途径,使用建筑阻碍结晶来制造可注射弹性体.
- 为了合成和表征具有可调节的机械性质的瓶移植共聚物 (A-g-B).
主要方法:
- 用聚乙烯糖醇 (PEG) 无形块和可结晶的聚乳酸 (PLA) 接种链合成瓶共聚合物.
- 利用密集移植的PEG刷来控制PLA移植的结晶率和程度.
- 在流体,糊状和弹性体类行为 (1-50 kPa模量) 中对机械性能的表征.
主要成果:
- 通过阻碍结晶实现了可注射弹性体的反应和无溶剂通路.
- 通过控制共聚合物架构和时间来证明机械性能的可调性.
- 开发了PLA-g-PEG糊剂,具有无溶剂可注射性和受时间控制的弹性体形成.
结论:
- 瓶刷移植共聚合物为无溶剂注射材料提供了一个多功能平台.
- 分子粘合剂平台对推进重建性手术,药物储存和组织工程具有前景.
- 对结晶的架构控制使生物医学应用中能够精确调整材料特性.
相关概念视频
02:57Surface Tension, Capillary Action, and Viscosity
Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
01:27Types of Fluids
Fluids can be classified into Newtonian and non-Newtonian fluids based on their response to shear stress. Newtonian fluids have a linear relationship between shear stress and the shear strain rate, following Newton's law of viscosity. Their viscosity remains constant regardless of the shear rate, making their behavior predictable and easier to analyze. Common examples include water, air, oil, and gasoline.
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and their...
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and their...