在长期COVID患者中,心脏自主功能减弱,正静血动力学受损
Rashmin Hira1, Jacquie R Baker1, Tanya Siddiqui1
1Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, GAC70 HRIC Building, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, Canada.
概括
长期冠状病毒病 (长期COVID) 损害了自主功能,在初始静止性低血压和姿势静止性静止性低心率综合征中出现明显的异常. 这些发现凸显了长期COVID病理生理学的多样性,需要量身定制的治疗.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 生理学 生理学 生理学
背景情况:
- 长期冠状病毒病 (长期COVID) 经常与自主功能障碍有关,包括静止性低血压和姿势静止性静止性心跳动综合征.
- 在这些血液动力学表型的长期COVID患者中,潜在的自主声调改变仍然不完全理解.
研究的目的:
- 为了比较长期COVID和健康对照患者之间的自主功能.
- 调查长期COVID子组内的自主差异,这些子组呈现出明显的正静性血液动力学概况.
主要方法:
- 在94名长期COVID患者 (按静止性低血压,静止性静止性心跳动综合征或没有异常分类) 和33名健康对照中,在10分钟的活跃姿势中评估了节拍对节拍的血液动力学.
- 对心血管自主健康的计算措施包括心率变化,血压变化和气息反射灵敏度.
- 统计分析涉及曼-惠特尼U和克鲁斯卡尔-瓦利斯测试,对连续数据进行恩的校正.
主要成果:
- 与对照组相比,长期COVID患者的直立高频心率波动和低频血压波动减少.
- 患有初始正静性低血压的患者比没有异常的患者表现出较低的卧底巴罗反射灵敏度.
- 与没有异常的患者相比,姿势静止性心跳动综合征患者的直立高频心率变化和巴罗反射灵敏度有所降低.
结论:
- 长期COVID的特征是心脏自主功能减弱,根据静态现象型,在巴罗反射灵敏度和交感/副交感调制中观察到特定的缺陷.
- 长期COVID亚组中的异质病理生理学强调了对个性化治疗策略的需求.
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