电子烟在怀孕和产后对母亲健康和血管功能在第四季度的影响
Amber Mills1,2, Duaa Dakhlallah3, Anand Ranpara1,2
1Department of Physiology, Pharmacology and Toxicology, West Virginia University School of Medicine, Morgantown, WV, USA.
Cardiovascular toxicology
|January 22, 2025
概括
怀孕期间使用电子烟 (Ecig) 会损害产后母亲的心血管和荷尔蒙健康,即使没有尼古丁. 这项研究揭示了持续的血管功能障碍和改变的循环因素,突出显示了暴露期以外的风险.
科学领域:
- 生殖生物学 生殖生物学
- 心血管生理学心血管生理学
- 毒理学 毒理学 毒理学
背景情况:
- 怀孕涉及显著的心血管适应,增加对延长产后不良结果的脆弱性.
- 怀孕期间电子烟 (Ecig) 的使用会影响母亲的心血管功能和后代的发育,但产后对母亲的影响尚不清楚.
研究的目的:
- 调查怀孕期间Ecig暴露对母体健康的长期产后影响.在老鼠模型中.
- 评估 Ecig vaping 在分娩后对母亲血管和内分泌功能的影响.
主要方法:
- 怀孕的Sprague Dawley大鼠从怀孕第二天到21日暴露于Ecig排放 (含尼古丁/调味剂或不含尼古丁/调味剂).
- 监测了产后,和水的健康状况,并评估了母亲的血管和内分泌功能.
- 分析了血管反应,激素水平和细胞外囊泡 (EV) 特性.
主要成果:
- Ecig暴露导致胎儿损失,并在断奶期间降低幼的存活率.
- 母亲的vaping诱导了血管和荷尔蒙功能障碍,包括减少了益生素和增加了大脑sirtuin 1 deacetylase.
- 观察到中脑动脉反应性受损和影响内皮功能的血EVs增加,在分娩后持续存在.
结论:
- 怀孕期间的ecig蒸汽,无论是尼古丁或调味品,都会改变影响母亲和胎儿健康的孕产妇循环因素.
- 循环的EV可能在产后血管功能障碍的发展中发挥作用.
- 在中,Ecig诱导的血管功能障碍的恢复可能需要比暴露窗口更长的时间.
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