在OGTT的悖论性GH反应并不能预测帕西里奥提德的有效性,但对葡萄糖代谢很重要
G Occhi1, G Voltan2,3, S Chiloiro4,5
1Department of Biology, University of Padova, Via Ugo Bassi 58/B, 35128, Padua, Italy. gianluca.occhi@unipd.it.
Journal of endocrinological investigation
|January 22, 2025
概括
葡萄糖负载后生长激素 (GH-Par) 的悖论性增加并不能预测巨治疗对利的反应. 然而,GH-Par可能表明代谢情况更差,影响治疗决策.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 巨症的特点是生长激素 (GH) 的过度分泌,通常是由于垂体腺瘤.
- 在口服葡萄糖负载 (GH-Par) 后,在约三分之一的壮病患者中观察到矛盾的GH增加.
- GH-Par与对第一代体静止素受体连接体 (fg-SRLs) 的更好的反应有关.
研究的目的:
- 为了研究GH-Par在壮病患者的表达性胺反应中的预测作用.
- 评估GH-Par与不良事件的发生之间的关联,特别是葡萄糖代谢变化 (GMA).
主要方法:
- 分析了一组意大利多中心追溯的59名积病患者,这些患者至少接受了3个月的沙利西治疗.
- 从口服葡萄糖耐受性测试 (OGTT) 中评估了患者的GH概况.
- 治疗反应的定义是IGF-1正常化或至少30%的减少.
主要成果:
- 在57名可评估患者中,帕西雷奥提德有效降低了IGF-1水平,在41名患者中有效降低了IGF-1,其中37名患者达到正常化.
- 在GH-Par (13名患者) 和非GH-Par (GH-NPar) 组之间,治疗疗效和持续时间相似.
- 在GH-NPar患者中,恶化的葡萄糖代谢变化 (GMA) 更频繁,可能是由于GH-Par组中先前存在的GMA的患病率更高.
结论:
- GH-Par并不能预测巨症患者对沙雷胺的治疗反应.
- GH-Par可能会预测在接受化治疗的壮病患者的代谢状况更差.
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