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Updated: Jun 16, 2025

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在急性髓性白血病中,GATA2将干与化疗耐药性联系在一起

Fatemeh Alikarami1,2, Hongbo M Xie1,3, Simone S Riedel1,2,4

  • 1Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.

Blood
|January 22, 2025
PubMed
概括

干细胞转录因子GATA2 (GATA结合蛋白2) 通过抑制p53介导的亡,促进急性髓性白血病 (AML) 中的化疗耐药性. 针对GATA2或其下游效应器RASSF4,可以克服AML患者的耐药性.

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