自主节奏组合训练减轻了多发性硬化症患者的氧化应激,炎症反应和超脂血症:一项随机对照试验
Sonda Jallouli1,2, Dana Jallouli3,4, Mariem Damak5
1Research laboratory: Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Archives of physiology and biochemistry
|January 22, 2025
概括
这项研究表明,12周的自我节奏高强度间歇训练和抵抗训练 (HIIT-RT) 在患有多发性硬化症 (PwMS) 的人群中显著降低了氧化应激,炎症和改善了身体组成. 这种运动方案为管理MS相关损害提供了一个有希望的方法.
科学领域:
- 运动生理学 运动生理学
- 神经免疫学 神经免疫学
- 代谢健康 代谢健康
背景情况:
- 多发性硬化症 (MS) 是一种影响中枢神经系统的慢性炎症性疾病.
- 氧化应激,炎症和改变的脂质样本都与MS的发病和进展有关.
- 在患有多发性硬化症的人群中,身体组成的变化很常见,可能会影响功能能力.
研究的目的:
- 为了研究一个为期12周的自动节奏组合高强度间歇训练和抵抗训练 (HIIT-RT) 计划的影响.
- 评估HIIT-RT对MS患者氧化应激,炎症和脂质特征生物标志物的影响.
- 为了评估在PwMS中HIIT-RT干预后身体组成的变化.
主要方法:
- 23名PwMS被随机分配到训练组 (TG,n=11) 或对照组 (CG,n=12).
- 该TG参与了为期12周的,每周三次自主节奏的HIIT-RT计划.
- 在干预前后测量生物标志物 (氧化应激,炎症,脂质概况,细胞损伤) 和身体成分.
主要成果:
- 与CG相比,TG显示了高级氧化蛋白产物,总醇,中性粒细胞,淋巴细胞和低密度脂蛋白胆固醇的显著减少.
- 与CG相比,在TG中观察到减少的谷氨显著增加.
- 与CG相比,TG表现出体重,体重指数和脂肪质量的显著下降.
结论:
- 自主节奏的HIIT-RT有效地减轻了氧化应激,炎症反应和PwMS中的超脂血症.
- 综合训练计划导致PwMS的身体组成显著改善.
- 在患有多发性硬化症的个体中,HIIT-RT提供了一种可行的治疗策略,以抵消与疾病相关的损害.
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