尼泊尔胆囊癌的危险因素:一种病例对照研究
Chanda Thakur1, Roshan Kumar Mahato2, Sabina Marasini1
1Department of Public Health, Kathmandu University Dhulikhel Hospital, Dhulikhel, Nepal.
PloS one
|January 22, 2025
概括
胆囊癌 (GBC) 是尼泊尔的一个重大健康问题. 这项研究确定了包括种族,酒精消费,农药暴露和饮食在内的关键风险因素,这些因素对于制定有针对性的公共卫生战略至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 胆囊癌 (GBC) 是一种罕见但高度致命的疾病,通常在晚期被诊断出来.
- 尼泊尔面临着高GBC负担,在全球发病率方面排名第四.
- 低生存率凸显了了解风险因素的迫切需要.
研究的目的:
- 研究社会人口,行为和环境因素与GBC发展之间的关联.
- 确定导致尼泊尔人口中GBC发病率的特定危险因素.
主要方法:
- 在2021/22期间进行了一项涉及240名参与者的病例控制研究 (120例,120例对照).
- 数据是通过使用结构化问卷的电话采访收集的.
- 无条件逻辑回归用于双变量和多变量分析,以确定赔率比率.
主要成果:
- 多变量分析揭示了显著的危险因素:平价≥3 (AOR=2.80),Terai/Madhesi族 (AOR=7.88),Janajati族 (AOR=3.36),以前的胆囊疾病 (AOR=2.00),高酒精消耗 (≥100ml/天,AOR=3.44),农药暴露 (≥2次/年,AOR=4.04),以及低水果/蔬菜摄入量 (AOR=2.69).
- 在病例和对照中都观察到女性占优势.
- 受访者的平均年龄为54.82±12.3岁.
结论:
- 该研究强调了尼泊尔GBC的关键风险因素,包括特定的族群,生活方式选择和环境暴露.
- 调查结果为制定有针对性的查计划和公共卫生干预提供了必要的数据.
- 这些见解对于资源分配和减轻尼泊尔GBC风险至关重要.
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