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Updated: May 31, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

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通过WWC蛋白质介导的补偿机制限制了由NF2导致的功能丧失所导致的脊髓炎

Xueying Wang1, Rui Zhu1, Pengcheng Yu1

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Science advances
|January 22, 2025
PubMed
概括

研究人员通过删除Nf2和Wwc1/2基因开发了一种与NF2相关的新型鼠标模型. 这种模型可以更快地进行临床前研究和神经瘤的药物查.

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