循环节律:无处不在,而且往往是逃避性的.
1ANID-Millennium Science Initiative Program-Millennium Institute for Integrative Biology (iBio), Santiago 8331150, Chile.
概括
循环时钟很普遍,但并不普遍存在. 这篇评论探讨了昼夜系统的演变,强调需要研究非模型生物来理解时钟功能.
科学领域:
- 生物学 生物学 生物学
- 进化生物学 进化生物学
- 时间生物学 时间生物学
背景情况:
- 昼夜时钟表现出不同种群的融合进化,从蓝藻细菌到人类.
- 然而,已知时钟组件的同类物在几个动物,原生体,真菌和细菌系中都不存在.
- 这就提出了关于昼夜系统的进化历史和多样性的问题.
研究的目的:
- 反思在研究非模型昼夜系统的挑战和开放问题.
- 强调研究缺乏正规时钟组件或可观测节奏的生物的重要性.
- 突出探索新型实验条件的必要性,以揭示隐藏的昼夜功能.
主要方法:
- 文献综述和综合关于昼夜时钟演变的当前知识.
- 对不同种类中核心时钟元素的基因组数据的分析.
- 讨论研究非模型生物中的节奏性的实验方法.
主要成果:
- 核心时钟元素的基因组识别并不总是与观察到的节律性相关.
- 环境线索 (非生物或营养) 通常需要在非模型系统中引起节奏行为.
- 没有已知的同类物或可观察到的节奏并不排除功能性昼夜钟的存在.
结论:
- 对非模型昼夜系统的研究对于全面了解生物定时至关重要.
- 需要进一步的研究来阐明影响时钟功能的机制和生理节律调节的进化途径.
- 重新考虑识别功能时钟的标准是必不可少的,超越依赖法典组件和可观察的节奏.
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