乌斯蒂洛辛A通过破坏细胞器功能来降低卵细胞质量
Jun Han1, Gang Wang1, Xin Liu1
1Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Agro-product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Key Laboratory for Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs /Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Environmental pollution (Barking, Essex : 1987)
|January 22, 2025
概括
乌斯提洛辛A (UA) 暴露会通过破坏组装和损害线粒体来阻止小鼠卵细胞的成熟. 这种真菌毒素通过引起细胞器功能障碍,氧化应激和卵细胞的亡来损害女性的生殖健康.
科学领域:
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 卵细胞质量对于成功受精和胚胎发育至关重要.
- 乌斯蒂洛辛A (UA) 是一种在大米中发现的真菌毒素,以其植物毒性和细胞毒性作用而闻名.
- UA对卵细胞成熟的影响以前没有被研究过.
研究的目的:
- 为了研究急性乌斯素A (UA) 暴露对小鼠卵细胞成熟的影响.
- 阐明UA影响卵细胞介质进展和细胞完整性的机制.
主要方法:
- 将小鼠卵细胞暴露在不同度的乌斯蒂洛辛A (UA) 中.
- 评估介质成熟,螺旋组装,动素密度和线粒体功能.
- 基因表达的分析与线粒体动力学,氧化应激,DNA损伤,ER应激和亡有关.
主要成果:
- 对UA的暴露以剂量依赖的方式抑制了卵细胞的成熟,导致介质性停止.
- 观察到螺旋组件的破坏,动蛋白密度降低,线粒体功能受损 (包括膜潜力和TOM20表达).
- UA诱导了氧化应激,DNA损伤,ER和戈尔吉功能障碍,ER应激 (增加GRP78),自和卵细胞的早期亡.
结论:
- 乌斯提洛辛A (UA) 通过破坏关键细胞器官和功能,显著损害小鼠卵细胞质量.
- 暴露于UA会导致介质性停止,线粒体功能障碍,氧化应激和亡,对女性的生殖潜力产生负面影响.
- 这些发现凸显了与乌斯蒂洛辛A (UA) 污染相关的潜在生殖风险.
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