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Updated: May 31, 2025

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
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跨类GPCR寡合化:通过A2AR调节mGlu5R激活的过程

Urszula Orzeł1, Carlos A V Barreto2, Sławomir Filipek3

  • 1PhD Programme in Biosciences, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal; Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal; Faculty of Chemistry, University of Warsaw, 02-093 Warsaw, Poland; Biological and Chemical Research Centre, University of Warsaw, 02-089 Warsaw, Poland.

International journal of biological macromolecules
|January 22, 2025
PubMed
概括

氨酸A2A受体 (A2A R) 结合到甲基氨酸受体5 (mGlu5 R) 调节受体的激活. 不活跃的A2A R阻断了mGlu5 R的激活,而活跃的A2A R则通过构造变化允许它.

关键词:
A(2A) RR 是一个字母.在GPCR中,GPCR是指GPCR.分子动力学分子动力学寡合化是指一种氧化物.mGlu(5)RR 这是一个很好的选择.

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