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Updated: May 31, 2025

4D Imaging of Protein Aggregation in Live Cells
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Published on: April 5, 2013

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变量域在推动全长光链中蛋白质毒性和聚合中的关键作用

Sarita Puri1, Angela Gadda2, Ivan Polsinelli3

  • 1Department of Biosciences, University of Milan, Italy; Biology Department, Indian Institute of Science Education and Research (IISER) Pune, India.

Journal of molecular biology
|January 22, 2025
PubMed
概括

免疫球蛋白轻链 (LC) 的变量 (VL) 域是轻链 (AL) 氨基粉症的关键. 这项研究揭示了VL和常数 (CL) 域如何相互作用,影响粉样纤维的形成和毒性.

关键词:
在AL氨基粉症症.抗体轻链是一种抗体轻链.聚合方式 聚合方式 聚合方式蛋白质结构动力学 蛋白质结构动力学可溶性毒性的可溶性毒性

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