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视网膜神经纤维层和高近视性玻璃眼中状层的长度变化:一项为期3年的队列研究

Jingwen Jiang¹, Kangjie Kong¹, Fengbin Lin¹

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

|January 22, 2025

概括

高度近视性玻璃眼 (HMG) 的眼睛显示了视网膜神经纤维层 (RNFL) 和状细胞内层 (GC-IPL) 稀薄的明显模式,与开角玻璃眼 (OAG) 相比. 更快的暂时RNFL稀释可能有助于识别高近视眼睛的青光眼.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.

背景情况:

高近视 (HM) 和开角光眼 (OAG) 是导致视力障碍的主要原因.
了解高度近视性玻璃眼 (HMG) 的独特结构变化对于诊断和管理至关重要.

研究的目的:

纵向评估光眼眼和没有光眼眼的高度近视 (HM) 眼睛的周周毛囊状视网膜神经纤维层 (pRNFL) 和黄斑结节细胞内状层 (mGC-IPL) 厚度变化.
调查高近视对pRNFL和mGC-IPL部门稀释模式的影响.

主要方法:

一项为期3年的纵向队列研究包括来自HM,OAG和HMG组的243个个体的243只眼睛.
扫描来源的OCT被用来测量平均和部门的PRNFL和mGC-IPL厚度.
线性混合效应模型分析了群体之间的稀释率和百分比.

主要成果:

在pRNFL和mGC-IPL中,HM,OAG和HMG眼睛表现出显著的纵向变薄 (P<0.001).
与OAG眼相比,HMG眼中的时间pRNFL稀释速度更快 (-1.24微米/年),相比之下,OAG眼中的时间pRNFL稀释速度更快 (-0.45微米/年;P=0.002).
与OAG相比,HMG眼睛在下部和时间pRNFL部门以及下鼻mGC-IPL部门显示出更高的百分比稀释率.

结论:

在HMG和OAG之间,pRNFL和mGC-IPL稀释的模式显著不同.
加快的时间pRNFL稀释可能成为高近视个体青光眼检测的关键指标.
这些发现有助于理解高近视的背景下眼损伤的致病性.

关键词:

高近视是指高近视的情况.图像成像是一种成像.其他国家和地区.视角开放的玻璃眼 (Open-angle glaucoma) 是一种视角开放的玻璃眼.

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