基于慢性鼻炎的内型和表型的纤毛节拍频率的变化
Asher C Park1, Theodore V Nguyen2, Lidek Chou3
1Beckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, California; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
概括
慢性鼻炎的亚型,包括异性,非异性和带鼻息肉的CRS,与对照组相比,表跳动频率降低. 光谱编码干涉度显微镜是一种可行的方法来测量这个功能.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸系统医学 呼吸系统医学
- 细胞生物学 细胞生物学
背景情况:
- 慢性鼻炎 (CRS) 根据鼻和内型 (eosinophilic/noneosinophilic) 进行分类.
- 在CRS中,对气道清除至关重要的粘膜功能受损.
- CRS亚型与粘膜膜功能之间的关系需要进一步研究.
研究的目的:
- 为了在不同的CRS亚型中比较纤毛节拍频率 (CBF).
- 为了验证光谱编码干涉度显微镜 (SEIM) 与相对照显微镜 (PCM) 对CBF评估.
主要方法:
- 在生理温度下使用PCM和SEIM对手术患者的鼻腔粘膜的ex vivo成像.
- 在对照组,带鼻息肉的CRS (CRSwNPs),没有鼻息肉的CRS (CRSsNPs),eosinophilic CRS和nonosinophilic CRS组之间比较了CBF测量.
- 通过PCM和SEIM获得的CBF测量的比较.
主要成果:
- CRSwNP粘膜表现出明显较低的CBF (5.77 ± 0.12 Hz) 比对照组 (6.23 ± 0.11 Hz).
- 与对照组 (6.28 ± 0.11 Hz) 相比,eosinophilic鼻炎 (5.74 ± 0.16 Hz) 和nonosinophilic CRS (6.00 ± 0.08 Hz) 均显示CBF显著减少.
- 在评估CBF时,PCM和SEIM之间没有发现显著差异 (P = .36).
结论:
- 与健康个体相比,埃索诺菲尔CRS,非埃索诺菲尔CRS和CRSwNP与状节拍频率降低有关.
- 在CRS研究中,SEIM展示了作为测量CBF的可靠方法的潜力.
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