B细胞透区分粘膜和皮肤的排斥模式在面部血管化的复合性全体移植中

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Martin Kauke-Navarro¹, William J Crisler², Nour Younis³

¹Department of Surgery, Division of Plastic Surgery, Yale School of Medicine, New Haven, Connecticut, USA.

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概括

面部全移植排斥在皮肤和粘膜之间有所不同. 粘膜排斥只涉及B细胞,这表明目前的监测方法可能会错过关键事件.

科学领域:

移植免疫学移植免疫学
血管化的复合性全移植 (VCA)
免疫细胞简介.

背景情况:

面部全移植排斥监测通常依赖于皮肤活检.
在VCA中粘膜排斥通常显示免疫活性升高.
皮肤和粘膜排斥之间的机制差异需要研究.

研究的目的:

调查皮肤和面部VCA的粘膜排斥背后的独特免疫机制.
为了比较免疫细胞透和基因表达在皮肤和粘膜异位移植.
确定潜在的生物标志物,以改善排斥检测.

主要方法:

对9名面部VCA接受者的活检进行了回顾性分析.
组织学,多重免疫染色和皮肤和粘膜的基因表达造型.
质量细胞测量用于外围血液单核细胞量化.

主要成果:

皮肤和粘膜都显示T细胞介导的排斥 (大酶B+T细胞).
粘膜表现出独特的B细胞透 (CD19 +,AHNAK +,CD43 +),在皮肤中不存在.
在联合排斥过程中,外周血液中的富含CD8+/GZMB+ T细胞和B细胞.

结论:

面部VCA排斥涉及皮肤和粘膜中的不同的机制,粘膜独特地涉及B细胞.
目前以皮肤为中心的监测可能会错过显著的粘膜体排斥事件.
同时监测皮肤和粘膜,包括粘膜活检,可以提高急性排斥检测.

关键词:

在VCA VCA中,您可以使用VCA.面部移植面部移植粘膜膜的粘膜的粘膜拒绝拒绝拒绝拒绝皮肤皮肤皮肤

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