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评估适应热的表型的分子生物标志物:一个叙事范围审查
J Corbett1, J S Young2, M J Tipton1
1Extreme Environments Laboratory, School of Sport Health and Exercise Sciences, University of Portsmouth, Portsmouth, UK.
The journal of physiological sciences : JPS
|January 22, 2025
概括
热适应 (HA) 提高了耐热性,但很难评估它. 目前的分子生物标志物缺乏准确性,需要进一步研究多系统方法以进行有效的评估.
科学领域:
- 运动生理学 运动生理学
- 环境健康 环境健康
- 生物标志物发现发现
背景情况:
- 热适应 (HA) 对于减轻热应激和改善在炎热环境中的身体表现至关重要.
- 评估HA疗效的传统方法依赖于生理标记,由于后勤,时间和成本的限制,这些标记往往是不切实际的.
- 一个可靠的HA分子生物标志物将简化热适应的评估.
研究的目的:
- 审查热适应 (HA) 的候选分子生物标志物.
- 评估目前HA的分子生物标志物候选者的敏感性和特异性.
- 探索未来发展热适应状态的有效分子生物标志物的方向.
主要方法:
- 关于热适应分子生物标志物的现有文献的叙述性综述.
- 检查与热适应相关的生理和分子反应.
- 对候选生物标记物的局限性和潜力的分析.
主要成果:
- 目前的HA分子生物标志物候选者表现出敏感性和特异性较差.
- 没有单个分子生物标志物作为热适应的明确指标出现.
- 综合来自多个生理系统的数据的多变量方法显示出有希望.
结论:
- 目前还缺乏用于热度适应的单一可靠的分子生物标志物.
- 开发一个有效的生物标志物需要克服与敏感性,特异性和系统集成相关的挑战.
- 未来的研究应该专注于多变量策略和确定热适应的新型分子指标.
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