确定结果领域,以建立渐进性肺纤维化核心结果集:一个范围审查
Anouk Delameillieure1, Vivien Somogyi2,3, Silja Schenk4
1Dept of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven - University of Leuven, Leuven, Belgium.
概括
这项研究确定了异常性肺纤维化 (IPF) 和渐进性肺纤维化 (PPF) 研究的关键结果领域. 调查结果将为改善临床护理和患者生活质量的核心成果提供信息.
科学领域:
- 肺部医学 肺部医学
- 临床研究方法论 临床研究方法论
- 患者报告的结果
背景情况:
- 异形性肺纤维化 (IPF) 和渐进性肺纤维化 (PPF) 显著损害生活质量和症状负担.
- 目前对IPF/PPF患者的临床护理不足于最佳水平,没有解决非医疗需求.
- 核心结果集 (COS) 对于在临床实践和研究中标准化结果测量至关重要.
研究的目的:
- 确定现有IPF/PPF研究中调查的结果领域.
- 这构成了为IPF/PPF开发COS的基本步骤.
主要方法:
- 根据乔安娜·布里格斯研究所和PRISMA指南进行了范围审查.
- 在PubMed,Embase和Web of Science中搜索了定量,定性和混合方法研究.
- 使用COMET分类学提取和分类结果,然后以感应方式将它们分组为域.
主要成果:
- 包括428篇论文,提取了1685个结果.
- 量化研究产生了64个结果领域,其中"全因生存"",肺功能"和"运动能力"是最常见的.
- 定性研究确定了51个领域,包括"做你喜欢的活动的能力"",焦虑,担忧和恐惧"和"应对疾病进展".
结论:
- 识别的多样化结果领域反映了IPF/PPF患者的复杂经验.
- 这些发现为开发COS提供了基础,以加强临床护理,并指导IPF/PPF的未来研究.
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