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在阴道环境中的乳酸调节了Candida-宿主相互作用

Diletta Rosati¹, Marisa Valentine², Mariolina Bruno¹

¹Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, T he Netherlands.

|January 22, 2025

概括

阴道中的乳酸增强了Candida albicans的生长和毒性. 这种适应改变了真菌细胞壁,损害了中性粒细胞的功能,并促进了炎症,这可能解释了复发性阴腺候群病.

科学领域:

菌类学菌类学是指菌类学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

Vulvovaginal candidiasis (VVC) 是一种常见的感染,由白虫 (Candida albicans) 引起的.
阴道环境富含由微生物群产生的乳酸.
乳酸在VVC病原和宿主真菌相互作用中的作用尚未完全理解.

研究的目的:

在阴道模拟环境中研究乳酸对Candida albicans适应和与人体免疫系统相互作用的影响.

主要方法:

在阴道模拟基质中与乳酸 (VSM+LA) 或没有乳酸 (VSM+LA) 的Candida albicans体外培养.
对真菌形态,细胞壁组成和免疫细胞反应 (中性粒细胞) 的分析.
对阴道上皮细胞的真菌损伤的评估.

主要成果:

乳酸增加了Candida albicans的扩散,细胞生长和上皮细胞损伤.
适应乳酸的真菌细胞表现出细胞壁的改变 (强壮的曼南,暴露的β-葡萄糖,低基).
尽管氧化反应增强,但中性粒细胞清除受损,并诱导训练免疫力.

结论:

菌对阴道乳酸的适应增加了毒性和免疫性,促进了促炎状态.
这些变化有助于免疫失调和中性粒细胞招募,这种情况在复发性VVC中可见.
乳酸是Candida albicans在阴道中的病原发生的一个关键因素.

关键词:

Vulvovaginal 候选症的发生在Candida Albicans中,它是最常见的.主机响应的主机响应.乳酸乳酸是什么意思乳酸是什么意思阴道模拟媒介的阴道模拟媒介.

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