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对帕奇米酸对三阴性乳腺癌的作用的机制性洞察力通过TOP2A向的TOP2A向

Ming Liu¹, Li Zheng², Yang Zhang³

¹Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, No.199 Donggang West Road, 730000, Gansu Province, China.

Scientific reports

|January 22, 2025

概括

帕奇米酸在治疗三阴性乳腺癌 (TNBC) 方面表现有前途,通过向TOP2A. 它的治疗作用可能涉及金药物耐药性途径和瘤免疫微环境.

科学领域:

药理学和瘤学药理学和瘤学
传统中国医药传统中国医药
生物信息学是一种生物信息学.

背景情况:

由于缺少雌激素/孕受体和HER2表达,三阴性乳腺癌 (TNBC) 缺乏向疗法.
传统中医 (TCM) 为TNBC提供了潜在的治疗策略.
帕奇米酸 (PA) 是TCM中的一种化合物,正在研究其抗TNBC机制.

研究的目的:

通过综合网络药理学和实验验验证,研究帕奇米酸 (PA) 对三阴性乳腺癌 (TNBC) 的治疗机制.
为了确定关键的分子点和受PA影响的途径在TNBC中.

主要方法:

从基因表达大巴 (GEO) 获取的TNBC微阵列数据.
使用六个数据库预测和选PA目标 (瑞士目标预测, HERB, ETCM, BATMAN, HIT, PharmMapper).
使用STRING构建了蛋白质-蛋白质相互作用 (PPI) 网络,进行了基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 丰富分析,进行了泛癌,瘤免疫微环境和分子对接分析,并进行了体外细胞实验 (细胞毒性,亡,增殖,迁移,入侵分析).

主要成果:

确定TOP2A作为TNBC治疗中PA的关键标.
金药物耐药性通路被确定为PA治疗作用的潜在KEGG通路.
PA的机制包括核分裂,染色体分离和线粒体过程.
抗胰岛素会影响瘤的免疫微环境,包括激活的树突细胞,乙素,以及各种巨细胞和T细胞亚型.
在不同TNBC亚型 (TNBC-BL1,TNBC-Metaplastic,TNBC-BL2) 中,PA显示出治疗潜力.

结论:

帕奇米酸 (PA) 对三阴性乳腺癌 (TNBC) 具有显著的治疗前景.
的有效性主要归因于其对TOP2A的作用以及其调节抗药途径.
对瘤免疫微环境和特定细胞过程的PA的影响有助于其抗TNBC作用.

关键词:

网络药理学网络药理学帕奇米酸是什么帕奇米酸是什么在TOP2A中.三重阴性乳腺癌是什么?试验室中的实验.

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