功能,认知障碍和轨迹:一个纵向双种族研究
Katharine L Cheung1,2, Miguel Arce Renteria3, Peter W Callas4
1University of Vermont College of Medicine, Burlington, VT, USA. klcheung@med.uvm.edu.
Journal of general internal medicine
|January 22, 2025
概括
慢性病与认知能力下降有关,特别是在中年. 白膜尿加速记忆丧失,特别是在中年.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 慢性病 (CKD) 是认知障碍的重要危险因素,特别是在老年人和黑人中.
- 了解CKD对不同年龄组和种族认知的不同影响对于有针对性的干预至关重要.
研究的目的:
- 调查CKD和事件认知障碍 (ICI) 之间的年龄和种族特定关联.
- 分析10年来患有和没有CKD的个体的认知轨迹.
主要方法:
- 全国范围内对22,435名年龄在45岁及以上的黑人和白人成年人进行的队列研究,没有基线认知障碍.
- 通过估计的膜过率 (eGFR) 和白蛋白与肌素比率 (ACR) 评估功能.
- 认知功能使用六项选器和领域特定测试评估超过10年,分析后勤回归和潜增长曲线模型.
主要成果:
- 慢性脏病指标 (低EGFR,高ACR) 与中年 (45-64岁) 的ICI与晚年 (≥65岁) 的ICI更强烈相关.
- 白蛋白尿 (ACR > 300) 与较低的初始认知评分和记忆功能的急剧下降有关,特别是在中年.
- 在CKD和认知障碍之间的关联中没有观察到任何显著的种族差异.
结论:
- 病和认知障碍之间的关联是年龄相关的,在中年时更为强烈.
- 白蛋白尿是认知能力下降的关键因素,特别是记忆功能,在中年人群中具有明显的影响.
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